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If your MOTU interface is not showing up in Audio MIDI Setup, MOTU Audio Setup, MOTU Discovery, or your DAW on High Sierra or later, you might need to enable the driver in your System Preferences. To enable the MOTU drivers, follow these steps: Download and install the very latest installer for your MOTU interface. The Mac OS X Audio/MIDI Setup utility is responsible for all Audio and MIDI data coming to and from your Mac, which makes it a valuable troubleshooting tool. The MIDI Setup in particular can come in handy if you begin to experience limited or no response from your MIDI device or if the device is not recognized at all. This guide will demonstrate how to create a new configuration.

Brent Daniels [Free] wrote:
.. I believe the problem is Audio Midi Setup. Even though I enable the correct stream and choose the correct speakers from with 'speaker configuration,' and even though the test tone buttons work over the appropriate speakers in that window, after I hit 'apply,' when playing multichannel audio files in QT7 or via Quicklook in the Finder, the problem persists (summing all channels to L & R speakers).
Furthermore, when I click 'Done' in the speaker config window and quit Audio Midi Setup and re-open it, the speaker configuration window reveals that my multichannel setup has reverted to Audio Midi Setup's intial state: a 2 channel (stereo) setup. I've done this at least ten times, as well as having deleted the AMS prefs and launched the utility in 32-bit mode with no success.'
Has anyone else with a multi-speaker setup had any problems with AMS initializing their speaker configuration, and just plain not working?

I don't know if this will help you, but I once had a problem with Audio Midi Setup forgetting its settings - I found that the settings were only securely stored if I made the changes while logged on as an administrator.

Audio Midi Setup Macbook

Audio Midi Setup Mac Not Working

Ms7001ea gas turbine ge. Mar 26, 2010 11:30 PM